Evaluating possible maternal effect lethality and genetic background effects in Naa10 knockout mice.
Amino-terminal (Nt-) acetylation (NTA) is a common protein modification, affecting approximately 80% of all human proteins.The human essential X-linked gene, NAA10, encodes for the enzyme NAA10, which is the catalytic subunit in the N-terminal acetyltransferase A (NatA) complex.There is extensive genetic variation in humans with missense, splice-si